Patterns of estrogen receptor expression across 18,500 tumor samples obtained from 149 cancer types

Presented in 13th Emirates Pathology, Digital Pathology & Cancer Conference Holiday Inn Dubai, UAE & Virtual
Poster Presenter Name: Dr. Florian Viehweger (Germany)
Global Journal of Pathology & Laboratory Medicine
Unified Citation Journals, Pathology 2024, ISSN 2754-0952
Biography: Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Florian Viehweger¹, Anne Menz¹, Doris Höflmayer¹, Christoph Fraune¹, Christian Bernreuther¹, Patrick Lebok¹, Sören Weidemann¹, Guido Sauter¹, Maximilian Lennartz¹, Till S Clauditz¹, Till Krech¹, Ronald Simon¹, Stefan Steurer¹, Sarah Minner¹, Eike Burandt¹, Natalia Gorbokon¹
Keywords: Immunohistochemistry, Estrogen receptor alpha (ER), normal and neoplastic tissues, tissue microarray

Abstract:
Estrogen receptor alpha (ER) is a nuclear transcription factor with a pivotal role in the function of the reproductive organs and of other organ systems. ER immunohistochemistry is used for the distinction of breast and gynecological tumors.
To comprehensively determine ER expression in normal and neoplastic tissues, a tissue microarray containing 18,560 samples from 149 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. ER positivity was found in 55 of 149 tumor categories, and 27 of these tumor categories contained at least one case with strong ER staining.
ER positivity was most seen in various subtypes of breast cancer (78.9-95.7%) and in several different tumor categories of the ovary and the endometrium (8.5-75.9%).
Other ER positive tumor entities included leiomyoma (65.9%), neuroendocrine tumor of the appendix (43.8%), leiomyosarcoma (22.9%), Sertoli Leydig cell tumor of the ovary (1 of 3 positive), rhabdomyosarcoma (16.7%), angiomyolipoma (10%), colorectal neuroendocrine carcinoma (9.1%), myoepithelial carcinoma of the salivary gland (8.3%), granulosa cell tumor of the ovary (8.3%), epithelial-myoepithelial carcinoma of the salivary gland (7.7%), squamous cell carcinomas of various sites of origin (0.8-6.7%), testicular teratoma (5.3%), Brenner tumor of the ovary (5.1%), and Ewing sarcoma (5%). Among 1,411 evaluable invasive breast carcinomas of no special type (NST), reduced ER immunostaining was linked to high BRE grade (p<0.0001), advanced pT stage (p<0.0001), distant metastasis (p=0.0012), HER2 overexpression and reduced progesterone receptor expression (p<0.0001 each). Among 378 high grade serous ovarian cancer, low ER immunostaining was linked to nodal metastasis (p=0.0112).
Our data provide a comprehensive overview on the pattern of ER expression in cancer and show that ER expression predominated in gynecological and breast tumors. However, occasional (strong) ER expression can also occur in a broad variety of non-breast and non-gynecological neoplasms.

Tags:
Cancer, Immunodeficiency States, Immunophenotyping, Molecular Diagnostics & Proteomics, Evolutionary Medicine, Functional Identification & Biomarkers, Hematopoietic & other Malignancies, Anatomical Pathology, Clinical Pathology, Dermato Pathology, Forensic Pathology, Hemato Pathology, Histopathology, Molecular Pathology, Surgical Pathology, Histopathology, Chemical Pathology, Hematopathology, Histopathology, Cytopathology, Forensic Pathology, Dermatopathology, Clinical Biochemistry, Infection Control, Cytokines, Enzymology, Endocrinology, Cellular Lineage, Virology, Rheology, Toxicology, Neuropathology, Diagnostic Pathology, Mesothelial Proliferations, Transfusion medicine, Clinical microbiology, Cytogenetics, Molecular Genetics Pathology, Immunopathology, Veterinary Pathology, Anatomical Pathology, General Pathology

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