KLK7 expression in human tumors: A tissue microarray study on 13,447 tumors

Presented in 13th Emirates Pathology, Digital Pathology & Cancer Conference Holiday Inn Dubai, UAE & Virtual
Poster Presenter Name: Dr. Simon Kind (Germany)
Biography: Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Global Journal of Pathology & Laboratory Medicine
Unified Citation Journals, Pathology 2023, ISSN 2754-0952

Simon Kind¹, Carolina Palacios Castillo, Ria Uhlig¹, Natalia Gorbokon¹, Maximilian Lennartz¹, Sebastian Dwertmann Rico¹, Viktor Reiswich¹, Florian Viehweger¹, Christian Bernreuther¹, Till S Clauditz¹, Christoph Fraune¹, Andrea Hinsch¹, Till Krech¹, Stefan Steurer¹, Eike Burandt¹, Sarah Minner¹, Ronald Simon¹, Guido Sauter¹, Anne Menz¹, Frank Jacobsen¹.

Keywords: Kallikrein-related peptidase 7 (KLK7), immunohistochemistry, tissue microarray; cancer; prognostic marker

Abstract:
Kallikrein-related peptidase 7 (KLK7) is a chymotrypsin-like serine protease which is essential for the desquamation of corneocytes and thus plays a pivotal role in maintaining skin homeostasis.
In cancer, KLK7 overexpression was suggested to represent a route for metastasis through cleavage of cell junction and extracellular matrix proteins of cancer cells.
To comprehensively determine KLK7 protein expression in normal and neoplastic tissues, a tissue microarray containing 13,447 samples from 147 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry.
KLK7 positivity was found in 64 of 147 tumor categories, including 17 tumor categories with at least one strongly positive case. The highest rate of KLK7 positivity was found in squamous cell carcinomas from various sites of origin (positive in 18.1%-63.8%), ovarian and endometrium cancers (4.8%-56.2%), salivary gland tumors (4.8%-13.7%), bilio-pancreatic adenocarcinomas (20.0%-40.4%), and adenocarcinomas of the upper gastrointestinal tract (3.3%-12.5%). KLK7 positivity was linked to nodal metastasis (p=0.0005), blood vessel infiltration (p=0.0037), and lymph vessel infiltration (p<0.0001) in colorectal adenocarcinoma, nodal metastasis in hepatocellular carcinoma (p=0.0382), advanced pathological tumor stage in papillary thyroid cancer (p=0.0132), and low grade of malignancy in a cohort of 719 squamous cell carcinomas from 11 different sites of origin (p<0.0001).
These data provide a comprehensive overview on KLK7 expression in normal and neoplastic human tissues.
The prognostic relevance of KLK7 expression and the possible role of KLK7 as a drug target need to be further investigated.

Tags:
Cancer, Immunodeficiency States, Immunophenotyping, Molecular Diagnostics & Proteomics, Evolutionary Medicine, Functional Identification & Biomarkers, Hematopoietic & other Malignancies, Anatomical Pathology, Clinical Pathology, Dermato Pathology, Forensic Pathology, Hemato Pathology, Histopathology, Molecular Pathology, Surgical Pathology, Histopathology, Chemical Pathology, Hematopathology, Histopathology, Cytopathology, Forensic Pathology, Dermatopathology, Clinical Biochemistry, Infection Control, Cytokines, Enzymology, Endocrinology, Cellular Lineage, Virology, Rheology, Toxicology, Neuropathology, Diagnostic Pathology, Mesothelial Proliferations, Transfusion medicine, Clinical microbiology, Cytogenetics, Molecular Genetics Pathology, Immunopathology, Veterinary Pathology, Anatomical Pathology, General Pathology

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