EXPLORING THE RELATIONSHIP BETWEEN GUT-BRAIN AXIS DYSFUNCTION AND PSYCHIATRIC COMORBIDITIES IN PATIENTS WITH GASTROINTESTINAL DISORDERS

March 2, 2024

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Presented in 13th World Gastroenterology, IBD & Hepatology Conference in Holiday Inn Dubai, Al Barsha, UAE & Virtual from December 15-17, 2023.

Poster Name: Dr. Pranav Reddy
Category: (Oral / Poster presentation / Workshop): Oral
Research interest: Gastroenterology, Microbiota, Gut-Brain Axis
Biography: Pranav Reddy has completed his B.S from Rutgers University School of Arts and Sciences. He is currently a student at Rowan-Virtua SOM. Priyamvada Joshi has completed her B.A. from Rutgers University School of Arts and Sciences. She is currently a student at Rowan-Virtua SOM.

Pranav Reddy 1 and Priyamvada Joshi 2,1 Affiliation for first author (30 Cummings Road Monmouth Junction, NJ 08852, Rowan-Virtua School of Osteopathic Medicine) for first author, 2Affiliation for second author (82 Jamie Court, Monmouth Junction, NJ 08852, Rowan-Virtua School of Osteopathic Medicine).

Global Journal of Gastroenterology & Hepatology Research [GJGHR]
Visit Poster presentation page: https://gastroenterology.universeconferences.com/speaker/pranav-reddy/

Introduction:
Background: The gut-brain axis (GBA) is a bidirectional communication pathway between the gastrointestinal tract (GI) and the central nervous system. Its dysfunction is implicated in GI and psychiatric conditions, as GI disorders are commonly accompanied by psychiatric comorbidities, but its exact role in psychiatric comorbidities is unclear [1,2].

Methods: PubMed and ScienceDirect databases were searched from 2017 to 2022 using specific terms including “[gut-brain axis dysfunction OR gut-brain axis OR microbiota-gut-brain axis] AND [gastrointestinal disorders OR gastrointestinal dysfunction] AND [psychiatric dysfunction OR psychiatric comorbidities OR psychiatric disorders]”. The selected publications were reviewed to draw conclusions and identify future research directions.[3].

Results: The case study investigated the influence of dysregulated GBA in individuals with comorbid IBS and depression, employing fecal transplantation as an intervention. The findings revealed notable enhancements in mood, medication efficacy, and symptomatology [3].

A retrospective study explored the impact of psychiatric comorbidity on treatment outcomes in patients with disorders of gut-brain interaction (DGBI). Anxiety disorders, a common comorbidity in DGBI patients, reduced the likelihood of treatment response to gastrointestinal medications, neuromodulators, targeting the GBA [5].

Conclusion: The studies highlight the intricate connection between the GBA, psychiatric comorbidities, and gastrointestinal disorders. Dysregulated gut microbiome and neurotransmitter alterations may contribute to psychiatric symptoms in gastrointestinal conditions. Future research should investigate the underlying mechanisms of GBA dysfunction and develop targeted interventions for better treatment outcomes in psychiatric comorbidities. Exploring specific gut microbial communities, diverse neuromodulators, and personalized GBA modulation offer potential for advancing our understanding and management of these disorders.

Keywords: Gut-brain axis, Gastrointestinal disorders, Psychiatric comorbidities, Dysregulated gut microbiome, Neurotransmitter alterations.

References: [1] Author J. A. (2018). Integr Med (Encinitas), 17(4):28-32. [2] Author M. C. et al. (2017) Clin Pract., 7(4):987. [3] Author R. C. et al. (2020) Medicine in Microecology, 6:100029. [4] Author Z. B. et al. (2022) Sci Rep, 12(1):1648. [5] Author E. M. et al. (2023) Neurogastroenterol Motil, 35(2):e14493.