Ketogenic Diet and timed fasting with Genotype guided supplementation for Type 2 Diabetes Reversal.

April 15, 2020

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Global Journal of Diabetes, Endocrinology & Metabolic Disorders
Volume 1, Issue 1, June 2020, Pages: 1-12
Received: Mar. 17, 2020; Accepted: Apr. 17, 2020; Published: Apr. 27, 2020

Authors: Ms. Manjari Chandra, Consultant Therapeutic and Functional Nutrition, Daivam Wellness, Gurugram, India.
A. Chopra, Medical Director and Head Functional Medicine, Daivam Wellness, Gurugram, India

Abstract:

Introduction:
According to the statistics published in American Diabetes Association (ADA) journal, there are more than 500 million prevalent cases of type 2 diabetes worldwide in the year 2018 and the prevalence is expected to increase in the future. This chronic disease is considered incurable mostly. Most of the conventional treatment options like bariatric surgery recommended by the International Diabetes Federation (IDF) and low-calorie intake recommended by ADA and the European Association for the Study of Diabetes (EASD) focus only on treatment not a reversal of type 2 diabetes. Micronutrient deficiently is also commonly observed in calorie-restricted diets so monitoring and supplementation are required for the overall wellness of the patients. Based on all these facts the present study was designed to observe the effect of a low-calorie diet with genotype-guided supplementation on diabetic patients.

Keywords: Type 2 Diabetes, Diabetes Association, Chronic Disease, Ketogenic Diet, Diabetic Patients.

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To citation of this article: Ms. Manjari Chandra, Ketogenic diet and timed fasting with genotype guided supplementation for type 2 diabetes reversal, Global Journal of Diabetes, Endocrinology & Metabolic Disorders

References:

KAISER AB, ZHANG N, DER PLUIJM W VAN. Global Prevalence of Type 2 Diabetes over the Next Ten Years (2018-2028). Diabetes. 2018 May;67(Supplement 1):202-LB.
Davies MJ, D’Alessio DA, Fradkin J, Kernan WN, Mathieu C, Mingrone G, et al. Management of hyperglycemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the study of Diabetes (EASD). Vol. 41, Diabetes Care. American Diabetes Association Inc.; 2018. p. 2669–701.
Damms-Machado A, Weser G, Bischoff SC. Micronutrient deficiency in obese subjects undergoing low-calorie diet. Nutr J. 2012;11:34.

Methodology: A literature search of Pubmed was done under subject headings diabetes reversal and calorie restriction. Based on the literature survey we proposed a study to check whether a ketogenic diet with reduced carbohydrate intake (20g) and supplements according to the genetic requirement of individuals results in diabetes reversal in ten patients (n=10).

Results: We found that 24h glucose curves normalized within two-three days of this dietary intervention in these patients. Also, a significant decrease in HbA1c levels (p value=0.007; Fig 1) without hypoglycemic medication and weight (p value=0.028; Fig 2) was observed in ten patients who took this genotype-guided ketogenic diet for three months. The average weight loss observed in these patients was 14kg with an average 5.3% fat loss. The diet was well tolerated by the patients and supplementation with the nutrients according to genetic predisposition helped in designing a personalized diet for the complete wellness of these patients.

Conclusion: Type 2 diabetes can be reversed with personalized dietary intervention. However, this approach requires complete lifestyle modification and proper support is required for monitoring and long-term behavioral change