Global Journal of Gastroenterology & Hepatology Research [GJGHR]
BACKGROUND AND AIM:
The incidence and prevalence of cirrhosis is increasing alarmingly day by day amounting to lot of morbidities and mortalities. Although lot of mortalities caused by acute variceal bleed but till date except invasive endoscopy measures, no other robust non-invasive measures were readily available to predict the presence of varix in cirrhotic. We aimed to assess the non-invasive role of total platelet count / splenic diameter (PC/SD) ratio in prediction of presence of esophageal varix in cirrhotics as previous reports supported their role in cirrhotic.
MATERIAL AND METHOD:
Consecutive cirrhotic cases attending the department of Gastroenterology and Hepaobiliary Sciences, IMS & SUM Hospital, Bhubaneswar during May 2020 to November 2021 were enrolled in this prospective observational cohort study and evaluated. All the patients were undergone endoscopy study to find out presence of esophageal varix and also assayed for the PC/SD ratio and relationship in-between them were explored by appropriate statistical analysis.
RESULTS:
Mean age of study population of total 125 cases was 53.85 ± 12.52 years. The area under operating curve (AUROC) for PC/SD, total platelet count and spleen diameter were found to be 0.84, 0.837 and 0.769 respectively in predicting the presence/ absence of esophageal varix. The cut-off values for PC/SD, platelet count, and spleen diameter were 1400, 138500/cmm, 95 mm respectively to accurately predict presence or absence of esophageal varix. In our study the patients with PC/SD, platelet count below the cut off value and spleen diameter above the cut off value had higher chances of having esophageal varix. The positive predictive values of respective cut off values were 82.56%, 79.56%, 72.64% respectively.
CONCLUSION:
The PC/SD ratio is a readily available non-invasive measure to accurately predict presence or absence of esophageal varix in cirrhotic, in particularly in those patients, where endoscopy is not feasible.
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Crohn’s and Colitis Journals | Gastroenterology & Hepatology Journals | Gastroenterology Journals | Research Gastroenterology and Hepatology Journals | Clinical and Experimental Gastroenterology Journals | Gastrointestinal Endoscopy Journals | Therapeutic Advances in Gastroenterology Journals | Colorectal Disease: clinical and molecular gastroenterology and surgery Journals | Inflammatory Bowel Diseases Journals | Expert Review of Gastroenterology & Hepatology Journals | Clinical Colorectal Journals | Cancer Gut Journals | Endoscopy Journals | Hepatitis B Annual Journals | Hepato-biliary-Pancreatic Sciences Journals | Medical Bulletin Journals
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