Keywords: low rectal cancer, abdominoperineal resection, neoadjuvant chemo radiation.
Introduction:
This study assessed the prognostic impact of key histopathological and clinicopathological factors on survival in patients with low rectal adenocarcinoma treated with neoadjuvant chemoradiation and abdominoperineal resection. This poster is based on our previously published work in Cureus [1] and is presented for educational purposes with author agreement.
Methods:
A retrospective cohort of 174 patients (2012–2019, National Cancer Institute – Cairo University) was analysed. Histopathological parameters and clinicopathological data were correlated with survival outcomes.
Results:
Median follow-up was 71.2 months. Median disease-free survival (DFS) was 69 months; median overall survival (OS) was not reached. High tumour grade significantly reduced OS (95% CI: 1.250–7.280; P = 0.014). Circumferential resection margin (CRM) ≤1 mm significantly reduced DFS (95% CI: 1.604–17.818; P = 0.006)
Conclusions:
Histopathological factors, particularly tumour grade and CRM status, are key prognostic indicators in low rectal adenocarcinoma. Their assessment is essential for accurate prognosis and guiding post-operative management
References:
[1] Fahim MI, Shafeik F, Allam RM, Asaad M, Taher M. Potential Prognostic Factors in Low Rectal Cancer Patients Treated With Neoadjuvant Chemoradiation and Abdominoperineal Resection. Cureus. 2025 Jun 1;17(6):e85171. doi:10.7759/cureus.85171
Biography: Dr. Marina Asaad is an Assistant Lecturer of Paediatrics at Cairo University Hospital, Egypt, with a Master’s degree in Paediatrics. She is engaged in clinical care, teaching, and academic research, and has co-authored three peer-reviewed publications, including a recent study on prognostic factors in low rectal cancer published in Cureus. With a growing interest in histopathology, especially gastrointestinal and oncologic pathology, she aims to transition into histopathology training in the United Kingdom, integrating her clinical background with pathology expertise to advance cancer diagnostics and patient care
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