Presented in 13th Emirates Pathology, Digital Pathology & Cancer Conference Holiday Inn Dubai, UAE & Virtual
Poster Presenter Name: Dr. Sebastian Dwertmann Rico (Germany)
Global Journal of Pathology & Laboratory Medicine
Unified Citation Journals, Pathology 2024, ISSN 2754-0952
Biography: Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Keywords: MUC6, tissue microarray, immunohistochemistry, cancer, diagnostic
Sebastian Dwertmann Rico1, Sebastian J A Schliesser1, Natalia Gorbokon1, David Dum1, Anne Menz1, Franziska Büscheck1, Andrea Hinsch1, Maximilian Lennartz1, Andreas M Luebke1, Christoph Fraune1, Patrick Lebok1, Till S Clauditz1, Frank Jacobsen1, Guido Sauter1, Ria Uhlig1, Stefan Steurer1, Sarah Minner1, Andreas H Marx2, Ronald Simon1, Eike Burandt1, Doris Hoeflmayer1, Till Krech1,3, and Christian Bernreuther1
1Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
2Department of Pathology, Academic Hospital Fuerth, Fuerth Germany,
3Institute of Pathology, Clinical Center Osnabrueck, Osnabrueck, Germany
Abstract:
Mucin 6 (MUC6) is a secreted gel-forming mucin covering the surfaces of gastrointestinal and other tissues. Published work demonstrates that MUC6 can also be expressed in several cancer types and can aid in the distinction of different tumor entities. To systematically analyze MUC6 expression in normal and cancerous tissues, a tissue microarray containing 15,412 samples from 119 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. At least a weak MUC6 positivity was seen in 50 of 119 (42%) tumor entities. 33 tumor entities included tumors with strong positivity. MUC6 immunostaining was most frequent in mucinous carcinomas of the breast (44%), adenocarcinomas of the stomach (30-40%) and esophagus (35%), and neuroendocrine carcinomas of the colon. Strong MUC6 staining was linked to advanced pT stage (p=0.0464), defective MMR status and right-sided tumor location (p<0.0001 each) in colorectal cancer, as well as to high tumor grade (p=0.0291), nodal metastasis (p=0.0485), HER2 positivity (p<0.0001) and negative ER (p=0.0332) / PR (p=0.0257) status in breast carcinomas of no special type. The results of this study show that MUC6 is expressed in a broad range of different tumor entities. Given that the rate of MUC6 positivity does not exceed 40% in any tumor entity, MUC6 expression analysis is not suited for the distinction of tumors of different sites of origin.
Tags:
Immunodeficiency States, Immunophenotyping, Molecular Diagnostics & Proteomics, Evolutionary Medicine, Functional Identification & Biomarkers, Hematopoietic & other Malignancies, Anatomical Pathology, Clinical Pathology, Dermato Pathology, Forensic Pathology, Hemato Pathology, Histopathology, Molecular Pathology, Surgical Pathology, Histopathology, Chemical Pathology, Hematopathology, Histopathology, Cytopathology, Forensic Pathology, Dermatopathology, Clinical Biochemistry, Infection Control, Cytokines, Enzymology, Endocrinology, Cellular Lineage, Virology, Rheology, Toxicology, Neuropathology, Diagnostic Pathology, Mesothelial Proliferations, Transfusion medicine, Clinical microbiology, Cytogenetics, Molecular Genetics Pathology, Immunopathology, Veterinary Pathology, Anatomical Pathology, General Pathology
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