Name: Annabel Serpico
Location: Spain
Category: (Poster Presentation)
Track name: Innovation and technology in Gastroenterology
Dr A. Serpico 1 and M.A. Poza 1Affiliation (Parque Científico de Madrid C/ Faraday 7 28049 Madrid
Biography: Annabel Serpico obtained a Master’s degree cum laude in molecular and industrial biotechnology at the Universitá degli Studi di Napoli (Italy) where she afterwards worked as pro-ject assistant on the enzymatic degradation of lignocellulosic biomasses. She obtained a PhD in chemistry at the University of Edinburgh, working on the development and optimization of bio-catalytic methods for the obtainment of chiral building blocks. She entered LEITAT technological center (Barcelona) as the biocatalysis R&D group leader within the biotechnology group. She joined Aora Health in 2021 as R&D researcher to work on the development of new innovative products to improve people’s health.
Global Journal of Gastroenterology & Hepatology Research [GJGHR]
Introduction: A healthy digestion is essential for overall health and wellbeing. Malfunction of the digestion system and pancreatic secretion of digestive enzymes can lead to a variety of conditions (e.g .dispepsia, chronic pancreatitis, cystic fibrosis) [1] .
In this case, enzyme replacement therapy is the main form of therapy and consists of the external supply of pancreatic enzymes to improve digestion and nutrition. Conventionally, enzymes supplementation in pancreatic disorders are enzymes from animal origin (porcine) and presents some limitations in terms of enzymatic activity and stability [2].
Aora Health has developed an innovative formulation based on microbe-derived enzymes, characterised by higher activity, a broader pH range of activity and higher stability compared to the animal-based counterparts [3,4]. Moreover, an innovative dual release delivery system has been developed to further protect the enzymes from the extreme stomach condition: the Cap In Cap (CIC). CIC is a ground-breaking selective technology, separating the external and internal capsule and allowing the delivery of the active principles in its specific site in the gastrointestinal tract to the optimal pH medium. The external capsule will disintegrate after entering the stomach, and the digestives enzymes selected to be released in the stomach will break down the food in less complex and absorbable nutrients, preventing indigestion and ensuring the delivery of a well-digested chime to the small intestine.
The internal capsule, made of a polymer designed to resist acidic conditions, will release its contents in the small intestine, where the selected enzymes will induce digestion of food as a replacement of pancreatic enzymes [5].
An in vitro study has demonstrated that the innovative formulation reduces the particle size (>2 mm) after food ingestion twice as much compared to the control [6]. This capability of acting at stomach and intestine levels could be potentially applied to a variety of gastrointestinal conditions.
Keywords: PERT, enzyme replacement therapy, gastrointestinal disease, cap in cap, innovative technology, microbial enzymes
References:
[1] Boland, M. J. Sci. Food Agric. 96, 2275–2283 (2016). [2]Armand, Fieker, A. P. & Philpott, CEG 55 (2011) [3] Khandke, D. A., Jain, S. K., Shirsath, P. A. & Manager, A. Indian Medical Gazette 11 (2013). [4]Schneider, M. U., Knoll-Ruzicka, M. L., Domschke, S., Heptner, G. & Domschke, W. Hepatogastroenterology 32, 97–102. [5]Roxas, M. Altern Med Rev. 2008 Dec;13(4):307-14. PMID: 19152478. [6]Dupont, D, Alric, M, Blanquet-Diot, S et al. (2019) Critical Reviews in Food Science and Nutrition, 59 (10). pp. 1546-1562. ISSN 1040-8398
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